HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2-(4-Nitronaphthalen-1-yloxy)propan-2-yl)pyridin-2-amine → 4-(2-(4-Aminonaphthalen-1-yloxy)propan-2-yl)pyridin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2-(4-Nitronaphthalen-1-yloxy)propan-2-yl)pyridin-2-amine | HCID 58532539 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Platinum | HCID 23939 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(2-(4-Aminonaphthalen-1-yloxy)propan-2-yl)pyridin-2-amine | HCID 67235172 | 99.1% |
Reaction Steps
A solution of 4-(2-(4-nitronaphthalen-1-yloxy)propan-2-yl)pyridin-2-amine (41) (282 mg, 0.87 mmol) in MeOH (45 mL) was passed through a Thales H-cube (1.0 mL·min−1, 30° C., 55 mm 10% Pt/C Cat-Cart, full hydrogen mode). The reaction mixture was evaporated in vacuo to afford the title compound (42) (253 mg, 89%) as a brown foam: m/z 294 (M+H)+ (ES+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299073B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-36843737043243a58ed3e926598e3b72 |
| Source note | uspto-grants-2012_10 |