(Z)-(4-bromobut-2-enyloxy)(tert-butyl)dimethylsilane → HCID 86618136, compound

HRID 20691Notes

Reaction equation

HRID 20691 reaction equation
Br[CH2:2]/[CH:3]=[CH:4]\[CH2:5][O:6][Si:7]([C:10]([CH3:13])([CH3:12])[CH3:11])([CH3:9])[CH3:8].[Cl:14][C:15]1[CH:16]=[N:17][CH:18]=[C:19]([Cl:36])[C:20]=1[NH:21][C:22]1[C:31]2[C:26](=[C:27]([OH:34])[C:28]([O:32][CH3:33])=[CH:29][CH:30]=2)[O:25][C:24](=[O:35])[CH:23]=1>>[Si:7]([O:6][CH2:5]/[CH:4]=[CH:3]\[CH2:2][O:34][C:27]1[C:28]([O:32][CH3:33])=[CH:29][CH:30]=[C:31]2[C:26]=1[O:25][C:24](=[O:35])[CH:23]=[C:22]2[NH:21][C:20]1[C:19]([Cl:36])=[CH:18][N:17]=[CH:16][C:15]=1[Cl:14])([C:10]([CH3:13])([CH3:12])[CH3:11])([CH3:9])[CH3:8]

Participants

3

Reactant 2

HCID 10999946(Z)-(4-bromobut-2-enyloxy)(tert-butyl)dimethylsilaneHCID 248495704-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxy-2H-chromen-2-one

Product 1

HCID 86618136HCID 86618136, compound

Procedure

(Z)-8-(4-(tert-Butyldimethylsilyloxy)but-2-enyloxy)-4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2H-chromen-2-one was prepared from (Z)-(4-bromobut-2-enyloxy)(tert-butyl)dimethylsilane and 4-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxy-2H-chromen-2-one (Example 29) following the procedure outlined in Example 25. MS (ESI): 537.0.

Sources & evidence

ORD record
ord-6bd9b665fe404a128ff9aa0808d88355
Source dataset
uspto-grants-2010_06
Patent number
US07745646B2

Reaction notes

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