HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 44594044, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | N,N-Dimethylpropargylamine | HCID 81643 | — |
| Reactant | HCID 58016054 | HCID 58016054 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 44594044 | HCID 44594044 | 68% |
Reaction Steps
2-Iodo-1,3-thiazolo[5,4-c]isoquinolin-5(4H)-one (0.1 g, 0.3 mmol), DMF (10 ml), 1-dimethylamino-2-propyne (0.25 g, 3.05 mmol), (Ph3P)2PdCl2 (10 mg), CuI (1 mg), and triethylamine (1.2 ml) were stirred at room temperature for 4 hours. The solvent was removed under reduced pressure and the mixture was chromatographed on SiO2 gel, eluting, with dichloromethane/methanol (98/2), to produce the title compound. Yield: 68% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299090B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-a29c051dbeb148f089ecca3d1007092e |
| Source note | uspto-grants-2012_10 |