Acetic Acid → HCID 86660488, compound

Participants

Reaction Steps

A solution of 2-methoxy-N-(4-(3-methoxy-4-nitrophenoxy)pyridin-2-yl)acetamide (400 mg, 1.20 mmol) in a mixture of DCM (5.0 mL), MeOH, (5.0 mL) and AcOH (0.5 mL) was subjected to hydrogenation by passage through a Thales H-cube (0.8 mL min−1, 60° C., 30 mm 10% Pt/C Cat-Cart, full hydrogen mode) and was then evaporated in vacuo to afford the title compound, Intermediate H6; Rt 1.10 min (Method 2); m/z 304 (M+H)+ (ES+). This sample, containing residual acetic acid, was used without further purification in the next step (below).

Provenance & Evidence