Trifluoroacetic acid → HCID 68491403, compound

Participants

Reaction Steps

To a solution of 9 (560 mg, 2.2 mmol) in CH2Cl2 (15 mL) was added trifluoroacetic acid (15 mL). The reaction mixture was stirred at room temperature for 30 min. The solvent was removed by rotary evaporation. The yellow oil was put under vacuum for 24 h to give crude amine 4b (579 mg, 2.2 mmol, 100%) as a yellow oil, which was used in the next step without further purification: 1H NMR (500 MHz, CDCl3) δ 1.10-1.30 (br s, 1H), 1.40-1.60 (br s, 1H), 2.30-2.50 (br s, 1H), 2.70-2.90 (br s, 1H), 6.70-6.72 (m, 1H), 6.72-6.77 (m, 1H), 6.89-7.00 (m, 1H), 7.10-7.30 (m, 1H), 7.80-8.20 (br s, 2H), 10.8-11.8 (br s, 1H); 13C NMR (125 MHz, CDCl3) δ 13.2, 21.5, 31.6, 113.5, 113.7, 114.2, 114.4, 122.29, 122.31, 130.4, 130.5, 140.1, 140.2, 162.2, 164.1; LCQ-MS (M+H+) calcd for C9H11FN 152. found 152; LC-TOF (M+H+) calcd for C9H11FN 152.08755. found 152.08703.

Provenance & Evidence