Imidazole → HCID 11646308, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 530 mg (1.665 mmol) of N-(6-fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide, 567 mg (8.325 mmol) of imidazole and 7.7 ml of dry 1,3-dimethyl-2-imidazolidinone is heated to 140° C. (oil bath temperature) for 90 minutes in a closed vial. After cooling, the dark solution is poured on 130 ml of water and the pH adjusted to ˜5 by adding 2 M acetic acid. The precipitate formed is filtered and recrystallized four times from DMSO/water, yielding 214 mg of the title compound as a red powder, m.p. >270° C.

Provenance & Evidence