1,3-Dimethyl-2-imidazolidinone → HCID 178455440, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 100 mg (0.314 mmol) of N-(6-fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide, 333 mg (1.57 mmol) of 4-(tert-butyl-dimethyl-silanyloxymethyl)-1H-imidazole and 1 ml of dry 1,3-dimethyl-2-imidazolidinone is heated to 140° C. (oil bath temperature) in a closed vial for 4 hours. After cooling, the orange solution is diluted with ethyl acetate and the organic phase washed with water and brine and dried over Na2SO4. Evaporation of the solvent gives an oil which is purified by medium pressure chromatography on silica gel with ethyl acetate/acetic acid 98:2 as eluent, yielding 53 mg of N-{6-[4-(tert-butyl-dimethyl-silanyloxymethyl)-imidazol-1-yl]-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl}-methanesulfonamide, m.p. >270° C.

Provenance & Evidence