Dimethylamine → HCID 11559229, compound

HRID 2069193Notes

Reaction equation

HRID 2069193 reaction equation
F[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[N:6]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:5]2=[O:21].[CH3:22][NH:23][CH3:24]>>[CH3:22][N:23]([CH3:24])[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[N:6]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:5]2=[O:21]

Participants

3

Reactant 2

HCID 674DimethylamineHCID 58964482N-(6-fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide

Product 1

HCID 11559229HCID 11559229, compound

Conditions

Temperature
150 °C

Procedure

A mixture of 100 mg (0.314 mmol) of N-(6-fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide and 0.185 ml (0.925 mmol) of dimethylamine (33% in ethanol) in a closed vial is heated in a microwave reactor at 150° C. for 15 minutes. After cooling, the reaction mixture is concentrated to dryness and the residue crystallized from tetrahydrofuran/water yielding 90 mg of the title compound as an orange powder, m.p. 245-260° C. (decomp.).

Workup

  1. temperatureAfter cooling
  2. concentrationthe reaction mixture is concentrated to dryness
  3. customthe residue crystallized from tetrahydrofuran/water yielding 90 mg of the title compound as an orange powder, m.p. 245-260° C. (decomp.)

Sources & evidence

ORD record
ord-5be3b4c89c24447f8645bc5b7ca5dde9
Source dataset
uspto-grants-2012_10
Patent number
US08299085B2

Reaction notes

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