Hydrochloric Acid → HCID 11703747, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 200 mg (0.63 mmol) of N-(6-fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide, 0.27 ml (2.51 mmol) of 2-methoxy-1-methyl-ethylamine and 3 ml ethanol is heated at 150° C. in a closed vial in a microwave reactor for 15 minutes. After cooling to room temperature, 1M aqueous hydrochloric acid is added until a pH value of 5-6 is reached. The resulting suspension is filtered, the residue washed with water and dried at 60° C. Crystallization from ether-hexane gives 82 mg (34%) of the title compound as red crystals, m.p. 103-111° C.

Provenance & Evidence