Dimethyl Sulfoxide → HCID 11539559, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 20 mg (0.062 mmol) of N-(6-fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide, 56 mg (0.372 mmol) of 4-bromo-1H-imidazole and 0.1 ml of DMSO is heated to 120° C. for 16 hours. After cooling to room temperature, the reaction mixture is distributed between ethyl acetate and water, the organic phase is separated, washed with water and brine, dried over sodium sulfate, filtered and evaporated. The residue is chromatographed on silica gel using dichloro-methane-methanol (95:5) and the fractions containing the desired product are combined and evaporated yielding 6 mg (21%) of the title compound. MS (ES−): m/e=445 (M−).

Provenance & Evidence