Dimethyl Sulfoxide → HCID 11539494, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 50 mg (0.156 mmol) of N-(6-fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide, 139 mg (0.936 mmol) of 4-phenyl-1H-imidazole and 0.25 ml of DMSO is heated to 120° C. for 3.5 hours. After cooling to room temperature, the reaction mixture is distributed between ethyl acetate and water, the organic phase is separated, washed with water and brine, dried over sodium sulfate, filtered and evaporated. The residue is chromatographed on silica gel using tetrahydrofuran-hexane (80:20) and the fractions containing the desired product are combined and evaporated giving 53 mg (77%) of the title compound. MS (ES−): m/e=441 (M−1−).

Provenance & Evidence