4-Fluorobenzylamine → HCID 11697508, compound

HRID 2069210Notes

Reaction equation

HRID 2069210 reaction equation
F[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[N:6]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:5]2=[O:21].[F:22][C:23]1[CH:30]=[CH:29][C:26]([CH2:27][NH2:28])=[CH:25][CH:24]=1>>[F:22][C:23]1[CH:30]=[CH:29][C:26]([CH2:27][NH:28][C:2]2[CH:3]=[C:4]3[C:9](=[CH:10][C:11]=2[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[N:6]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:5]3=[O:21])=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 673264-FluorobenzylamineHCID 58964482N-(6-fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide

Product 1

HCID 11697508HCID 11697508, compoundYield 12.5%

Procedure

N-(6-Fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide (30 mg, 0.0943 mmol) is reacted with 4-fluoro-benzylamine according to the GPA affording 5 mg (12.5%) of a red powder. Rt=5.00 min.

Sources & evidence

ORD record
ord-88d1cce1c8f84b4fb280e78db56ce219
Source dataset
uspto-grants-2012_10
Patent number
US08299085B2

Reaction notes

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