HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazin-4-ylacetophenone → N-{6-[4-(4-Acetyl-phenyl)-piperazin-1-yl]-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl}-methanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazin-4-ylacetophenone | HCID 97269 | — |
| Reactant | N-(6-fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide | HCID 58964482 | — |
| Product | N-{6-[4-(4-Acetyl-phenyl)-piperazin-1-yl]-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl}-methanesulfonamide | HCID 11533446 | 44% |
Reaction Steps
N-(6-Fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide (20 mg, 0.0628 mmol) is reacted with 1-(4-piperazin-1-yl-phenyl)-ethanone according to the GPA affording 14 mg (44%) of an orange powder. Rt=3.85 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299085B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-51befb2bc2164034b0cdb33ab78976f5 |
| Source note | uspto-grants-2012_10 |