HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxypyrrolidine → N-[6-(3-Hydroxy-pyrrolidin-1-yl)-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl]-methanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxypyrrolidine | HCID 98210 | — |
| Reactant | N-(6-fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide | HCID 58964482 | — |
| Product | N-[6-(3-Hydroxy-pyrrolidin-1-yl)-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl]-methanesulfonamide | HCID 11545484 | 58% |
Reaction Steps
N-(6-Fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide (30 mg, 0.0943 mmol) is reacted with pyrrolidin-3-ol according to the GPA affording 21 mg (58%) of a red powder. Rt=4.22 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299085B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-9defc8a90e8649a390341e1d83ad0e8d |
| Source note | uspto-grants-2012_10 |