N-(6-fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide → HCID 69451151, compound

HRID 2069229Notes

Reaction equation

HRID 2069229 reaction equation
F[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[N:6]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:5]2=[O:21].[NH:22]1[CH:26]=[C:25]([CH2:27][C:28]([N:30]2[CH2:35][CH2:34][O:33][CH2:32][CH2:31]2)=[O:29])[N:24]=[CH:23]1>>[N:30]1([C:28](=[O:29])[CH2:27][C:25]2[N:24]=[CH:23][N:22]([C:2]3[CH:3]=[C:4]4[C:9](=[CH:10][C:11]=3[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[N:6]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:5]4=[O:21])[CH:26]=2)[CH2:31][CH2:32][O:33][CH2:34][CH2:35]1

Participants

3

Reactant 2

HCID 58964482N-(6-fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamideHCID 178520353HCID 178520353, compound

Product 1

HCID 69451151HCID 69451151, compoundYield 39%

Procedure

N-(6-Fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide (30 mg, 0.0943 mmol) is reacted with 2-(1H-imidazol-4-yl)-1-morpholin-4-yl-ethanone according to the GPB affording 18.1 mg (39%) of a yellow powder. Rt=4.37 min

Sources & evidence

ORD record
ord-11d262f5a0dd4393b46d6cc9d8ee5780
Source dataset
uspto-grants-2012_10
Patent number
US08299085B2

Reaction notes

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