2-(Methylamino)ethanol → HCID 69343361, compound

HRID 2069230Notes

Reaction equation

HRID 2069230 reaction equation
F[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[N:6]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:5]2=[O:21].[CH3:22][NH:23][CH2:24][CH2:25][OH:26]>>[OH:26][CH2:25][CH2:24][N:23]([CH3:22])[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[N:6]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:5]2=[O:21]

Participants

3

Reactant 2

HCID 80162-(Methylamino)ethanolHCID 58964482N-(6-fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide

Product 1

HCID 69343361HCID 69343361, compoundYield 71%

Procedure

N-(6-Fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide (30 mg, 0.0943 mmol) is reacted with 2-methylamino-ethanol according to the GPA affording 25 mg (71%) of an orange-dark powder. Rt=2.98 min.

Sources & evidence

ORD record
ord-0d945b5261584acab46622e5043d9fee
Source dataset
uspto-grants-2012_10
Patent number
US08299085B2

Reaction notes

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