4,5-Dimethyl-1H-imidazole → HCID 11560274, compound

HRID 2069234Notes

Reaction equation

HRID 2069234 reaction equation
F[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[N:6]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:5]2=[O:21].[CH3:22][C:23]1[N:24]=[CH:25][NH:26][C:27]=1[CH3:28]>>[CH3:22][C:23]1[N:24]=[CH:25][N:26]([C:2]2[CH:3]=[C:4]3[C:9](=[CH:10][C:11]=2[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[N:6]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:5]3=[O:21])[C:27]=1[CH3:28]

Participants

3

Reactant 2

HCID 753064,5-Dimethyl-1H-imidazoleHCID 58964482N-(6-fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide

Product 1

HCID 11560274HCID 11560274, compoundYield 48%

Procedure

N-(6-Fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide (30 mg, 0.0943 mmol) is reacted with 4,5-dimethyl-1H-imidazole according to the GPB affording 18 mg (48%) of a white powder. Rt=2.43 min.

Sources & evidence

ORD record
ord-b1dbf8be5cee4f719119e4962d0ba20b
Source dataset
uspto-grants-2012_10
Patent number
US08299085B2

Reaction notes

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