N-(6-fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide → HCID 69451893, compound

HRID 2069236Notes

Reaction equation

HRID 2069236 reaction equation
F[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[N:6]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:5]2=[O:21].[CH2:22]([NH:25][C:26](=[O:33])[CH2:27][C:28]1[N:29]=[CH:30][NH:31][CH:32]=1)[CH:23]=[CH2:24]>>[CH2:22]([NH:25][C:26](=[O:33])[CH2:27][C:28]1[N:29]=[CH:30][N:31]([C:2]2[CH:3]=[C:4]3[C:9](=[CH:10][C:11]=2[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[N:6]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:5]3=[O:21])[CH:32]=1)[CH:23]=[CH2:24]

Participants

3

Reactant 2

HCID 58964482N-(6-fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamideHCID 178457759HCID 178457759, compound

Product 1

HCID 69451893HCID 69451893, compoundYield 52%

Procedure

N-(6-Fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide (30 mg, 0.0943 mmol) is reacted with N-allyl-2-(1H-imidazol-4-yl)-acetamide according to the GPA affording 28 mg (52%) of a yellowish powder. Rt=2.36 min.

Sources & evidence

ORD record
ord-8d8ef37ee1074b5cb947b4ef5ba7435d
Source dataset
uspto-grants-2012_10
Patent number
US08299085B2

Reaction notes

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