N-BOC-ethylenediamine → HCID 69338207, compound

HRID 2069237Notes

Reaction equation

HRID 2069237 reaction equation
F[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[N:6]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:5]2=[O:21].[C:22]([O:26][C:27](=[O:32])[NH:28][CH2:29][CH2:30][NH2:31])([CH3:25])([CH3:24])[CH3:23]>>[C:22]([O:26][C:27](=[O:32])[NH:28][CH2:29][CH2:30][NH:31][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[N:6]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:5]2=[O:21])([CH3:25])([CH3:23])[CH3:24]

Participants

3

Reactant 2

HCID 187201N-BOC-ethylenediamineHCID 58964482N-(6-fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide

Product 1

HCID 69338207HCID 69338207, compoundYield 62%

Procedure

N-(6-Fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide (30 mg, 0.0943 mmol) is reacted with (2-amino-ethyl)-carbamic acid tert-butyl ester according to the GPA affording 27 mg (62%) of a red powder. Rt=4.43 min.

Sources & evidence

ORD record
ord-5f7735a1ca3a4263918f42d5c0b78a40
Source dataset
uspto-grants-2012_10
Patent number
US08299085B2

Reaction notes

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