L-Alaninol → HCID 69343450, compound

HRID 2069241Notes

Reaction equation

HRID 2069241 reaction equation
F[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[N:6]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:5]2=[O:21].[NH2:22][C@@H:23]([CH3:26])[CH2:24][OH:25]>>[OH:25][CH2:24][C@@H:23]([NH:22][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[N:6]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:5]2=[O:21])[CH3:26]

Participants

3

Reactant 2

HCID 80307L-AlaninolHCID 58964482N-(6-fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide

Product 1

HCID 69343450HCID 69343450, compoundYield 61%

Procedure

N-(6-Fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide (30 mg, 0.0943 mmol) is reacted with (S)-2-amino-propan-1-ol according to the GPA affording 21.4 mg (61%) of a red powder. Rt=3.20 min.

Sources & evidence

ORD record
ord-b45000fd507b4267a9e3e250bb70d557
Source dataset
uspto-grants-2012_10
Patent number
US08299085B2

Reaction notes

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