N-(6-fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide → HCID 178505187, compound

HRID 2069253Notes

Reaction equation

HRID 2069253 reaction equation
F[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[N:6]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:5]2=[O:21].[NH2:22][C@H:23]([CH2:26][C:27]1[N:28]=[CH:29][NH:30][CH:31]=1)[CH2:24][OH:25]>>[OH:25][CH2:24][C@H:23]([NH:22][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[N:6]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:5]2=[O:21])[CH2:26][C:27]1[N:28]=[CH:29][NH:30][CH:31]=1

Participants

3

Reactant 2

HCID 58964482N-(6-fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamideHCID 178511836HCID 178511836, compound

Product 1

HCID 178505187HCID 178505187, compoundYield 43%

Procedure

N-(6-Fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide (30 mg, 0.0943 mmol) is reacted with (R)-2-amino-3-(1H-imidazol-4-yl)-propan-1-ol according to the GPA affording 22.7 mg (43%) of a red powder. Rt=1.73 min.

Sources & evidence

ORD record
ord-bc26ae508cc044759482b92f4df332e9
Source dataset
uspto-grants-2012_10
Patent number
US08299085B2

Reaction notes

Loading…