N-(6-fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide → HCID 69347645, compound

HRID 2069255Notes

Reaction equation

HRID 2069255 reaction equation
F[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[N:6]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:5]2=[O:21].[CH3:22][O:23][CH2:24][C:25]1[N:26]=[CH:27][NH:28][CH:29]=1>>[CH3:22][O:23][CH2:24][C:25]1[N:26]=[CH:27][N:28]([C:2]2[CH:3]=[C:4]3[C:9](=[CH:10][C:11]=2[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[N:6]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:5]3=[O:21])[CH:29]=1

Participants

3

Reactant 2

HCID 58964482N-(6-fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamideHCID 178494610HCID 178494610, compound

Product 1

HCID 69347645HCID 69347645, compoundYield 44%

Procedure

N-(6-Fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide (50 mg, 0.157 mmol) is reacted with 4-methoxymethyl-1H-imidazole according to the GPB affording 36 mg (44%) of a yellow powder. Rt=2.20 min.

Sources & evidence

ORD record
ord-62df7d2501944abe82a16fa4d6394fc7
Source dataset
uspto-grants-2012_10
Patent number
US08299085B2

Reaction notes

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