HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2-(acetylamino)-5-nitro-4-(trifluoromethyl)benzoate → Methyl 2-acetamido-5-amino-4-(trifluoromethyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2-(acetylamino)-5-nitro-4-(trifluoromethyl)benzoate | HCID 58964493 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 2-acetamido-5-amino-4-(trifluoromethyl)benzoate | HCID 58964516 | 103.1% |
Reaction Steps
A solution of 1.7 g (5.55 mmol) of 2-acetylamino-5-nitro-4-trifluoromethyl-benzoic acid methyl ester in 29 ml of methanol is treated with 250 mg of Pd/C (10%) and the mixture stirred under 5 bars of hydrogen for 20 minutes. The mixture is filtered and the filtrate concentrated in vacuo to give 1.58 g (quantitative) of 2-acetylamino-5-amino-4-trifluoromethyl-benzoic acid methyl ester as yellow crystals, m.p. 143-152° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299085B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-d9f3206da0324822a5c3b3d8f56a9006 |
| Source note | uspto-grants-2012_10 |