Phosgene → HCID 58964497, compound

HRID 2069275Notes

Reaction equation

HRID 2069275 reaction equation
[CH3:1][O:2][C:3](=[O:22])[C:4]1[CH:9]=[C:8]([O:10][C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)[C:7]([C:17]([F:20])([F:19])[F:18])=[CH:6][C:5]=1[NH2:21].[C:23](Cl)(Cl)=[O:24]>>[CH3:1][O:2][C:3](=[O:22])[C:4]1[CH:9]=[C:8]([O:10][C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)[C:7]([C:17]([F:19])([F:20])[F:18])=[CH:6][C:5]=1[N:21]=[C:23]=[O:24]

Participants

3

Reactant 2

HCID 6371PhosgeneHCID 58964525HCID 58964525, compound

Product 1

HCID 58964497HCID 58964497, compound

Procedure

300 mg of 2-amino-5-(pyridin-3-yloxy)-4-trifluoromethyl-benzoic acid methyl ester are treated with phosgene according to the procedure described in example 74, yielding 291 mg of 2-isocyanato-5-(pyridin-3-yloxy)-4-trifluoromethyl-benzoic acid methyl ester as a brownish oil. 1H-NMR (CDCl3): 8.50 br s, 1H; 8.40 s, 1H; 7.60 s, 1H; 7.50 s, 3H; 3.95 s, 3H.

Sources & evidence

ORD record
ord-6f9ff831f1234218a2c2472d5f6a0201
Source dataset
uspto-grants-2012_10
Patent number
US08299085B2

Reaction notes

Loading…