Methylamine → HCID 58964513, compound

Participants

Reaction Steps

5-Fluoro-2-nitro-4-trifluoromethyl-benzoic acid methyl ester (300 mg, 1.12 mmoles) is dissolved in dioxane and after addition of methylamine (0.490 ml, 3.5 eq.) the yellow mixture is stirred at room temperature for 2 days. The mixture is evaporated to dryness. Dichloromethane is added and the suspension is filtrated. Evaporation of the filtrate yielded 2-nitro-5-methylamino-4-trifluoromethyl-benzoic acid methyl ester as a yellow solid (291.3 mg, 95.4% yield). The product is used in the next step without further purification.

Provenance & Evidence