HCID 58964513, compound → HCID 58964515, compound

Participants

Reaction Steps

2-Nitro-5-methylamino-4-trifluoromethyl-benzoic acid methyl ester is dissolved in methanol/tetrahydrofuran and after addition of 10% Pd-C, the mixture is stirred for 45 min. at room temperature under hydrogen. The mixture is filtrated over celite and evaporated under reduced pressure to give 2-amino-5-methylamino-4-trifluoromethyl-benzoic acid methyl ester as an orange oil (240 mg, 103% yield). The product is used in the next step without further purification.

Provenance & Evidence