4-Chlorophenyl chloroformate → HCID 58964518, compound

Participants

Reaction Conditions

Reaction Steps

4-chlorophenyl chloroformate (26 mg, 1.1 eq.) is slowly added to a solution of 5-(acetyl-methyl-amino)-2-amino-4-trifluoromethyl-benzoic acid methyl ester (36 mg, 0.12 mmoles) in dioxane (0.2 ml). The solution is stirred at 80° C. for 2 hours. The solution is evaporated to yield 5-(acetyl-methyl-amino)-2-(4-chloro-phenoxycarbonylamino)-4-trifluoromethyl-benzoic acid methyl ester after repeated trituration with hexane. Used tel quel for the next step.

Provenance & Evidence