Sodium Hydroxide → HCID 11618895, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-(3-methanesulfonylamino-2,4-dioxo-7-trifluoromethyl-1,2,3,4-tetrahydro-quinazolin-6-yl)-1H-imidazole-4-carboxylic acid methyl ester (150 mg, 0.335 mmol) in 10 ml dimethylformamide are added 1.7 ml of 1 M aqueous sodium hydroxide solution and stirred at room temperature for one hour and at 50° C. for two hours. After cooling to room temperature the solvent is evaporated in vacuo, the residue taken up in water, acidified with 5 ml of 1 M hydrochloric acid and extracted three times with 15 ml each of dichloromethane. The organic layer is dried over sodium sulfate, filtered and evaporated to give 126 mg (0.29 mmol, 87%) of amorphous 1-(3-methanesulfonylamino-2,4-dioxo-7-trifluoromethyl-1,2,3,4-tetrahydro-quinazolin-6-yl)-1H-imidazole-4-carboxylic acid, ES-MS: m/z 434 [M+H]+.

Provenance & Evidence