Formamide → HCID 11711704, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 1-(3-methanesulfonylamino-2,4-dioxo-7-trifluoromethyl-1,2,3,4-tetrahydro-quinazolin-6-yl)-1H-imidazole-4-carboxylic acid methyl ester (50 mg, 0.112 mmol) and formamide (0.15 ml, 0.374 mmol) in 5 ml of dimethylformamide is heated to 120° C. and sodium methylate (6 mg, 0.112 mmol) is added under stirring. After two hours at 120° C. the solution is cooled to room temperature, evaporated in vacuo and the residue chromatographed to give 30 mg (0.069 mmol, 62%) of amorphous 1-(3-methanesulfonylamino-2,4-dioxo-7-trifluoromethyl-1,2,3,4-tetrahydro-quinazolin-6-yl)-1H -imidazole-4-carboxylic acid amide, ES-MS: m/z 433 [M+H]+.

Provenance & Evidence