2,5-Dimethoxytetrahydrofuran → HCID 11625241, compound

Participants

Reaction Steps

The solution of 80 mg (0.236 mmol) ) N-(6-amino-2,4-dioxo-7-trifluoromethyl-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide and 0.092 ml (0.709 mmol) 2,5-dimethoxy-tetrahydrofuran in 1.5 ml acetic acid is refluxed for 2 hours. After rotavapor evaporation of the solvent the residue is purified by reversed phase chromatography (C18) with an acetonitril-water gradient and the product is lyophilized to give 54 mg (59%) of N-(2,4-dioxo-6-pyrrol-1-yl-7-trifluoromethyl-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide as a brown solid. MS (ES+): m/e =389 (M+H+).

Provenance & Evidence