Tetrahydro-2,5-dimethoxyfuran-3-carbaldehyde → HCID 11538926, compound

Participants

Reaction Steps

To a solution of 100 mg (0.296 mmol) of N-(6-amino-2,4-dioxo-7-trifluoromethyl-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide in 2 ml acetic acid is added a solution of 2,5-dimethoxy-tetrahydrofuran-3-carbaldehyde in 1 ml acetic acid and the mixture is refluxed for 3 hours. The solvent is removed by rotavapor evaporation and the brown oil is purified by reversed phase chromatography (C18) with an acetonitril-water gradient to give 80 mg (65%) of N-[6-(3-formyl-pyrrol-1-yl)-2,4-dioxo-7-trifluoromethyl-1,4-dihydro-2H-quinazolin-3-yl]-methanesulfonamide as a black solid. MS (ES+): m/e =417 (M+H+).

Provenance & Evidence