Hydrochloric Acid → HCID 58964472, compound

Participants

Reaction Steps

A solution of 20 mg (0.04 mmol) of 1-(3-benzenesulfonylamino-2,4-dioxo-7-trifluoromethyl-1,2,3,4-tetrahydro-quinazolin-6-yl)-1H-imidazole-4-carboxylic acid in 50 ml of a 6 M solution of hydrochloric acid in methanol is stirred at 70° C. for two days. Every half day another 50 ml of a 6 M solution of hydrochloric acid in methanol is added. Subsequently the solvent and hydrochloric acid are evaporated to yield 1-(3-benzenesulfonylamino-2,4-dioxo-7-trifluoromethyl-1,2,3,4-tetrahydro-quinazolin-6-yl)-1H-imidazole-4-carboxylic acid methyl ester: 1H-NMR; DMSO-d6 (400 MHz, ppm): 8.16 (s, 1H, imidazole); 8.10 (s, 1H, aromatic); 7.98 (s, 1H, imidazole); 7.70 (s, 1H, aromatic); 3.79 (s, 3H, COOCH3). LC-MS: 510 [M+H]+; Agilent LC/MSD 1100 Series, LC-MS method: Column: SunFireC8, 4.6*50 mm, 3.5 μm; positive MS; water/acetonitril 95:5 to 5:95 in 5 min, flow: 1.5 ml/min.

Provenance & Evidence