Sodium hydride → HCID 59149664, compound

Participants

Reaction Steps

100 ml of dry dimethyl sulfoxide were added slowly to a mixture of 9.30 g (42.3 mmol) of trimethylsulfoxonium iodide and 976 mg (40.1 mmol) of sodium hydride. The mixture was stirred at room temperature for 15 min, and then 8.5 g (31.3 mmol) of 3-[6-(4-fluoro-phenyl)-pyridin-3-yl]-acrylic acid ethyl ester were added. The reaction mixture was stirred at room temperature for 18 h and then poured onto ice/water and extracted with ethyl acetate. The combined organic phases were dried and evaporated. The obtained raw product was purified by column chromatography (silica gel, dichloromethane). Yield: 6.75 g.

Provenance & Evidence