HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2069320Generated: October 30, 2026
Dimethyl Sulfoxide → Ethyl 4-(3-dimethylaminopyrrolidin-1-yl)benzoate
https://huagongshe.com/reaction/2069320
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Benzoic acid, 4-fluoro-, ethyl ester | HCID 67976 | — |
| Reactant | 3-(Dimethylamino)pyrrolidine | HCID 2758519 | — |
| Solvent | Water | HCID 962 | — |
| Product | Ethyl 4-(3-dimethylaminopyrrolidin-1-yl)benzoate | HCID 69209289 | — |
Reaction Steps
A mixture of ethyl 4-fluorobenzoate (4.47 g), dimethylpyrrolidin-3-ylamine (3.04 g), potassium carbonate (3.68 g) and dimethyl sulfoxide (20 ml) was heated at 130° C. for 7 hours. After cooling, the mixture was diluted with water and extracted with methyl tert-butyl ether. The organic phase was washed with water, dried over magnesium sulfate, filtered and concentrated. The product with the molecular weight of 262.35 (C15H22N2O2) was obtained in this way; MS (ESI): 263 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08299104B2 |
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| Source dataset | uspto-grants-2012_10 |
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| ORD ID | ord-aa0261af899647a399602288366ed17f |
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| Source note | uspto-grants-2012_10 |
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