Potassium tert-butoxide → HCID 66933571, compound

HRID 2069396Notes

Reaction equation

HRID 2069396 reaction equation
[CH2:1]([O:3]C1N=C(C(O)=O)C=C(CC)N=1)C.C([O:17][C:18]([C:20]1[CH:25]=[C:24]([CH2:26][CH:27]([CH3:29])[CH3:28])[N:23]=[C:22](S(C)(=O)=O)[N:21]=1)=[O:19])C.CC([O-])(C)C.[K+]>CO>[CH2:26]([C:24]1[N:23]=[C:22]([O:3][CH3:1])[N:21]=[C:20]([C:18]([OH:17])=[O:19])[CH:25]=1)[CH:27]([CH3:29])[CH3:28]

Participants

5

Reactant 3

HCID 23665647Potassium tert-butoxideHCID 66933396HCID 66933396, compoundHCID 66933435HCID 66933435, compound

Product 1

HCID 66933571HCID 66933571, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound is obtained as a yellow oil (82 mg) in analogy to 2-ethoxy-6-ethyl-pyrimidine-4-carboxylic acid starting from 6-isobutyl-2-methanesulfonyl-pyrimidine-4-carboxylic acid ethyl ester, KOtBu and methanol; LC-MS: tR=0.77 min, [M+H]+=210.96.

Sources & evidence

ORD record
ord-d4a8b5b39f1849b0be32a5697c29dd17
Source dataset
uspto-grants-2012_10
Patent number
US08299086B2

Reaction notes

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