Sodium Hydroxide → HCID 86645307, compound

Participants

Reaction Steps

To a solution of 4-[5-(2-diethylamino-6-methyl-pyrimidin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenol (700 mg, 1.90 mmol) in isopropanol (12 mL), are added 3M aq. NaOH (4 mL) and R-epichlorohydrine (1.49 mL, 19.0 mmol). The reaction mixture is stirred at rt for 15 h, then is diluted with EtOAc and washed with 1M aq. NaOH followed by brine. The org. phase is dried over Na2SO4, filtered, evaporated and purified by CC (eluting with Heptane/EtOAc 4:1) to give the title compound as a yellow oil (882 mg); LC-MS: tR=1.23; [M+H]+=424.04. 1H NMR (CDCl3) δ 1.25 (t, J=7.0 Hz, 6H), 1.33 (t, J=7.5 Hz, 3H), 2.41 (s, 3H), 2.47 (s, 3H), 2.79 (m, 3H), 2.94 (t, J=4.5 Hz, 1H), 3.42 (m, 1H), 3.76 (q, J=7.0 Hz, 4H), 3.83 (dd, J=11.0, 5.8 Hz, 1H), 4.13 (dd, J=11.0, 3.0 Hz, 1H), 7.23 (s, 1H), 7.89 (d, J=5.5 Hz, 2H).

Provenance & Evidence