反应详情

N((S)-3-{4-[5-(2-Diethylamino-6-methyl-pyrimidin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide is prepared in analogy to N—((S)-3-{2-ethyl-4-[5-(2-ethylamino-6-methyl-pyrimidin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide using 2-diethylamino-6-methyl-pyrimidine-4-carboxylic acid; LC-MS: tR=1.03 min; [M+H]+=499.23. 1H NMR (D6-DMSO): δ 1.18 (t, J=7.0 Hz, 6H), 1.22 (t, J=7.3 Hz, 3H), 2.35 (s, 3H), 2.44 (s, 3H), 2.73 (q, J=7.3 Hz, 2 H), 3.25 (m, 1H), 3.44 (m, 1H), 3.67 (q, J=7.0 Hz, 4H), 3.76 (m, 2H), 3.84 (d, J=5.8 Hz, 2H), 3.96 (m, 1H), 5.31 (d, J=5.0 Hz, 1H), 5.55 (t, J=5.5 Hz, 1H), 7.30 (s, 1H), 7.69 (t, J=5.5 Hz, 1H), 7.78 (s, 2H).