反应详情

rac-3-{4-[5-(2-Isobutylamino-6-methyl-pyrimidin-4-yl)-[1,2,4]oxadiazol-3-yl]-2,6-dimethyl-phenoxy}-propane-1,2-diol is prepared in analogy to rac-3-{4-[5-(2-ethylamino-6-methyl-pyrimidin-4-yl)-[1,2,4]oxadiazol-3-yl]-2,6-dimethyl-phenoxy}-propane-1,2-diol using 2-isobutylamino-6-methyl-pyrimidine-4-carboxylic acid; white crystalline solid; LC-MS: tR=0.90 min*; [M+H]+=428.25; 1H NMR (D6-DMSO): δ 0.93 (d, J=6.8 Hz, 6H), 1.91 (m, 1H), 2.35 (s, 6H), 2.41 (s, 3H), 3.18 (m, 2H), 3.50 (t, J=5.5 Hz, 2H), 3.75 (dd, J=5.5 and 8.8 Hz, 1H), 3.79-3.91 (m, 2H), 4.64 (t, J=5.5 Hz, 1H), 4.96 (d, J=5.0 Hz, 1H), 7.28 (s, 1H), 7.65 (s br, 1H), 7.76 (s, 2H).