1,2-Dichloroethane → HCID 68508615, compound

Participants

Reaction Steps

To a solution of glycolic acid (33 mg, 0.43 mmol) and DIPEA (146 μL, 0.85 mmol) in DMF (5 mL) is added EDC (82 mg, 0.43 mmol) followed by HOBt (58 mg, 0.43 mmol). The reaction mixture is stirred at rt for 10 min before adding Intermediate 12 (100 mg, 0.28 mmol). Stirring is continued for 18 h and the reaction mixture is then diluted with EtOAc, washed with sat. aq. NaHCO3, dried over MgSO4, filtered and evaporated. The residue is purified by prep. TLC (eluting with DCM/7M NH3 in MeOH 10:1) to give the title compound (50 mg) as a yellow solid; tR=1.05 min; [M+H]+=411.75.

Provenance & Evidence