Dichloromethane → HCID 59180256, compound

HRID 2069484Notes

Reaction equation

HRID 2069484 reaction equation
[CH2:1]([O:3][C:4](=[O:8])[C@H:5]([CH3:7])[NH2:6])[CH3:2].ClCCl.Cl[CH2:13]/[CH:14]=[CH:15]\[CH2:16]Cl.CCCCCC>CCCCCC.C(OCC)(=O)C>[N:6]1([C@@H:5]([CH3:7])[C:4]([O:3][CH2:1][CH3:2])=[O:8])[CH2:16][CH:15]=[CH:14][CH2:13]1

Participants

6

Reactant 4

HCID 6344DichloromethaneHCID 8058HexaneHCID 76507L-Alanine ethyl esterHCID 64321151,4-Dichloro-cis-2-butene

Product 1

HCID 59180256HCID 59180256, compoundYield 56.7%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

From L-alanine ethyl ester (383 mg, 3.2 mmol), dichloromethane (0.1 ml) and cis-1,4-dichloro-2-butene (140 mg, 1.0 mmol). Flash chromatography: silica gel, gradient neat hexane to hexane:ethyl acetate (1:2) afforded the product (96 mg, 52%) as yellow oil.

Sources & evidence

ORD record
ord-3c7df3d6b611434f8c9afba0281a6a3c
Source dataset
uspto-grants-2012_10
Patent number
US08299113B2

Reaction notes

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