HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 59180251, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Hexane | HCID 8058 | — |
| Reactant | Methyl phenylglycinate, L- | HCID 1201451 | — |
| Reactant | 1,4-Dichloro-cis-2-butene | HCID 6432115 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | HCID 59180251 | HCID 59180251 | 65.2% |
Reaction Steps
From L-phenylglycine methyl ester (808 mg, 4.89 mmol), dichloromethane (0.1 ml) and cis-1,4-dichloro-2-butene (170 mg, 1.39 mmol). Flash chromatography: silica gel, gradient neat hexane to hexane:ethyl acetate (1:2) afforded the product (197 mg, 65%) as colourless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299113B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-d91d5a0b337e4401a93671902e938940 |
| Source note | uspto-grants-2012_10 |