Trifluoroacetic acid → HCID 57561728, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 4-cyclopentanecarbonyl-1H-pyrrole-2-carboxylic acid methyl ester (A1-I) and trifluoroacetic acid was added triethylsilylhydride drop wise under stirring at 0-5° C. Stirring was further continued for 20 hours at 0-25° C. Trifluoroacetic acid was removed under reduced pressure and the residue was diluted with diethyl ether, ether layer was separated and washed with 1N NaOH followed by brine, organic layer was dried over anhydrous sodium sulfate and was evaporated to yield 4-cyclopentylmethyl-1-H-pyrrole-2-carboxylic acid ethyl ester (A1-II).

Provenance & Evidence