Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 4-(Bromomethyl)-1,2-difluorobenzene | HCID 581436 | — |
| Reactant | HCID 59576364 | HCID 59576364 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 59576358 | HCID 59576358 | — |
Reaction Steps
A mixture of 4-isobutyryl-1H-pyrrole-2-carboxylic acid methyl ester (B1-I) and cesium carbonate were stirred in dry DMF for 10 minutes at 40-50° C. To it 1-bromomethyl-3,4-difluorobenzene was added and the reaction was stirred for 18 hrs at 50° C. Water was added to the reaction and extracted with ethyl acetate. The organic layer was washed with brine and dried over anhydrous sodium sulfate. The solvent was evaporated to obtain 1-(3,4-difluoro-benzyl)-4-isobutyryl-1H-pyrrole-2-carboxylic acid methyl ester (B1-II).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08299115B2 |
|---|
| Source dataset | uspto-grants-2012_10 |
|---|
| ORD ID | ord-b8805788970040cca03560810d409a58 |
|---|
| Source note | uspto-grants-2012_10 |
|---|
