2-Thiophenesulfonyl chloride → HCID 59576359, compound

Participants

Reaction Steps

To a solution of thiophene-2-sulfonyl chloride in dichloromethane was added aluminum chloride at 0-5° C., 1H-pyrrole-2-carboxylic acid methyl ester in dichloromethane was added slowly. Reaction mixture was stirred from room temperature to 60° C. for 24 hrs. On completion of reaction; reaction mixture was poured over crushed ice and extracted with dichloromethane, organic layer was washed with 1 N NaOH solution and brine, dried over anhydrous sodium sulfate, filtered and concentrated to afford 4-(thiophene-2-sulfonyl)-1H-pyrrole-2-carboxylic acid methyl ester (D1-I).

Provenance & Evidence