Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 4-(Bromomethyl)-1,2-difluorobenzene | HCID 581436 | — |
| Reactant | HCID 59576359 | HCID 59576359 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Cesium carbonate | HCID 10796 | — |
| Product | HCID 59576362 | HCID 59576362 | — |
Reaction Steps
To a solution of 4-(thiophene-2-sulfonyl)-1H-pyrrole-2-carboxylic acid methyl ester (D1-I) in dry dimethylformamide, cesium carbonate was added at 40-50° C. To this was added 3,4-difluro benzyl bromide and stirred overnight at 40-50° C. Reaction mixture was taken in to water and extracted with ethyl acetate, organic layer was washed with water and brine, dried over anhydrous sodium sulfate, filtered and concentrated to afford 1-(3,4-difluoro-benzyl)-4-(thiophene-2-sulfonyl)-1H-pyrrole-2-carboxylic acid methyl ester (D1-II).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08299115B2 |
|---|
| Source dataset | uspto-grants-2012_10 |
|---|
| ORD ID | ord-490bd75ce3f84caba3cc8d02ac8a4780 |
|---|
| Source note | uspto-grants-2012_10 |
|---|
