Potassium Hydroxide → HCID 59576357, compound

Participants

Reaction Steps

To a solution of 1-(3,4-difluoro-benzyl)-4-(thiophene-2-sulfonyl)-1H-pyrrole-2-carboxylic acid methyl ester (D1-II) in ethanol was added potassium hydroxide in water and stirred overnight at room temperature. Solvent was removed under reduced pressure; the residue was taken in water and washed with diethyl ether. The aqueous layer was acidified with dilute HCl and precipitate was extracted with ethyl acetate. The organic layer was washed with water and brine, dried over anhydrous sodium sulphate, filtered and concentrated to afford 1-(3,4-difluoro-benzyl)-4-(thiophene-2-sulfonyl)-1H-pyrrole-2-carboxylic acid (D1-III).

Provenance & Evidence