Methanol → HCID 59576361, compound

Participants

Reaction Steps

(5-Chloro-2-{[1-(2,4-difluoro-benzyl)-4-isobutyl-1H-pyrrole-2-carbonyl]-amino}-thiazol-4-yl)-acetic acid ethyl ester was taken in THF and methanol and to it lithium hydroxide monohydrate in water was added and stirred for 16-18 hrs. at room temperature. After completion of the reaction, the solvent was evaporated; the residue was diluted with water and was washed with diethyl ether. The aqueous layer was acidified with 1N HCl and extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous sodium sulfate and evaporated the solvent to get the title compound (5-Chloro-2-{[1-(2,4-difluoro-benzyl)-4-isobutyl-1H-pyrrole-2-carbonyl]amino}-thiazol-4-yl)-acetic acid (E1).

Provenance & Evidence