5-fluoro-1-(3-fluorobenzyl)-1H-indole-2-carboxylic acid → HCID 44181664, compound

Participants

Reaction Steps

The process is performed according to a method similar to that of Example 1.2, starting with 0.5 g (1.74 mmol) of 5-fluoro-1-(3-fluorobenzyl)-1H-indole-2-carboxylic acid prepared in step 1.1 and 0.345 g (2.09 mmol) of 6-amino-2-methylthiazolo[5,4-b]pyridine (Yakugaku Zasshi 1950, 70, 187). At the end of the reaction, the product is concentrated under reduced pressure and then taken up in 100 mL of water. A precipitate is collected by filtration, and is purified by chromatography on a column of alumina, eluting with a mixture of dichloromethane and methanol. The resulting product is recrystallized from methanol, and a solid is collected by filtration, and dried under reduced pressure. 340 mg of the expected product are thus isolated.

Provenance & Evidence