3-Methyl-3H-imidazo[4,5-b]pyridin-6-amine → 5-Fluoro-1-[(3-fluorophenyl)methyl]-N-(3-methyl-3H-imidazo[4,5-b]pyridin-6-yl)-1H-indole-2-carboxamide

HRID 2069529Notes

Reaction equation

HRID 2069529 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[N:10]=[CH:9][N:8]([CH3:11])[C:5]2=[N:6][CH:7]=1.[F:12][C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[N:18]([CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[CH:24]=1)[C:17]([C:30](O)=[O:31])=[CH:16]2>>[CH3:11][N:8]1[C:5]2=[N:6][CH:7]=[C:2]([NH:1][C:30]([C:17]3[N:18]([CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[CH:24]=4)[C:19]4[C:15]([CH:16]=3)=[CH:14][C:13]([F:12])=[CH:21][CH:20]=4)=[O:31])[CH:3]=[C:4]2[N:10]=[CH:9]1

Participants

3

Reactant 2

HCID 232983793-Methyl-3H-imidazo[4,5-b]pyridin-6-amineHCID 574315135-fluoro-1-(3-fluorobenzyl)-1H-indole-2-carboxylic acid

Product 1

HCID 668897505-Fluoro-1-[(3-fluorophenyl)methyl]-N-(3-methyl-3H-imidazo[4,5-b]pyridin-6-yl)-1H-indole-2-carboxamide

Procedure

Compound 7 is synthesized according to a process similar to that described in Example 1.2, starting with 6-amino-3-methyl-3H-imidazo[4,5-b]pyridine, described in the preceding step, and 5-fluoro-1-[(3-fluorophenyl)methyl]-1H-indole-2-carboxylic acid, described in step 1.1.

Sources & evidence

ORD record
ord-7e842cb339ed46fe86401d1b20f32399
Source dataset
uspto-grants-2012_10
Patent number
US08299114B2

Reaction notes

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