HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 2-(2-Bromo-4-chlorophenoxy)cyclopentanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Chlorocyclopentanone | HCID 12751 | — |
| Reactant | Ethyl 2-bromo-4-chlorophenol | HCID 67404132 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 2-(2-Bromo-4-chlorophenoxy)cyclopentanone | HCID 58566778 | 71% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
To a solution of ethyl 2-bromo-4-chlorophenol (10.9 g, 52.5 mmol) in acetone (105 mL) was added potassium carbonate (14.5 g, 105 mmol), followed by 2-chlorocyclopentanone (6.3 mL, 63 mmol). The mixture was refluxed at 100° C. overnight, then filtered through celite, concentrated in vacuo and purified by flash chromatography on silica gel (20% EtOAc in hexanes) to provide 2-(2-bromo-4-chlorophenoxy)cyclopentanone (516B) (10.8 g, 71.0%) as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299117B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-8b5b35aa46304e5889f90b7e768d917e |
| Source note | uspto-grants-2012_10 |